HCID 86595505, Verbindung → Alacepril

HRID 1375696

Reaktionsgleichung

Reaktionsgleichung von HRID 1375696
C([O:5][C:6](=[O:32])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:23])[C@H:16]([CH3:22])[CH2:17][S:18][C:19](=[O:21])[CH3:20])(C)(C)C>FC(F)(F)C(O)=O.C(Cl)Cl>[C:19]([S:18][CH2:17][C@@H:16]([CH3:22])[C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([NH:8][C@H:7]([C:6]([OH:32])=[O:5])[CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:24])=[O:23])(=[O:21])[CH3:20]

Komponenten

3

Edukt 1

HCID 86595505HCID 86595505, Verbindung

Produkt 1

HCID 71992AlaceprilAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863450Trifluoroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

1-[(2S)-3-(Acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-L-phenylalanine tert-butyl ester (1.19 g, 0.025 Mol) was dissolved in a solution of trifluoroacetic acid:CH2Cl2 (1:2, 30 ml) and the reaction was stirred at room temperature for 1 hour. Then it was evaporated under reduced pressure affording 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-L-phenylalanine as a clear oil (1.00 g, 100%) that was used in the subsequent reaction without any further purification.

Aufarbeitung

  1. customThen it was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5176682f705445cfa7456e5068f0c417
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07169805B2

Verknüpfte Notizen

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