Potassium Hydroxide → HCID 22499406, Verbindung

HRID 1375955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1375955
[I:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16](C(OCC)=O)[CH2:15][CH2:14]2)=[CH:9][CH:8]=1)=[O:5].[OH-].[K+]>>[I:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)=[CH:11][CH:12]=1)=[O:5]

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 86590841HCID 86590841, Verbindung

Produkt 1

HCID 22499406HCID 22499406, Verbindung

Versuchsvorschrift

A mixture of intermediate (27) (0.041 mol) and potassium hydroxide (0.41 mol) in ispropanol (200 ml) was stirred and refluxed for 3 hours and the solvent was evaporated till dryness. Water was added. The mixture was extracted with DCM and the solvent was evaporated, yielding 2-iodo-N-[4-(1-piperazinyl)phenyl]benzamide (intermediate 28).

Aufarbeitung

  1. temperaturerefluxed for 3 hours
  2. customthe solvent was evaporated till dryness
  3. additionWater was added
  4. extractionThe mixture was extracted with DCM
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-937d1f98f94f424394a491e72feab36a
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07169796B2

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