Sodium Hydroxide → 5-(N-Methylamino)methylimidazo[5,1-b]thiazole

HRID 1376601Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1376601
[CH3:1][N:2]([CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1)C(=O)C(F)(F)F.[OH-].[Na+]>CO>[CH3:1][NH:2][CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 229167005-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole

Produkt 1

HCID 212624035-(N-Methylamino)methylimidazo[5,1-b]thiazoleAusbeute 109,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 394 mg (1.49 mmol) of the above-obtained 5-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole in 3 ml of methanol was added 3 ml of a 10% aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 1 hour. The methanol was distilled off under reduced pressure. The resultant was extracted three times with chloroform. The organic layer was dried over anhydrous potassium carbonate, and concentrated under reduced pressure to give 272 mg of the title compound as an oil.

Aufarbeitung

  1. distillationThe methanol was distilled off under reduced pressure
  2. extractionThe resultant was extracted three times with chloroform
  3. dry with materialThe organic layer was dried over anhydrous potassium carbonate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b23bb46eae8742218a636a1c5b8af5e5
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05663162

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