4-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate → HCID 70050186, Verbindung

HRID 1376678

Reaktionsgleichung

Reaktionsgleichung von HRID 1376678
NCC(N[C@H](C([NH:17][C@H:18]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH:19]([CH3:21])[CH3:20])=O)CC(=O)OC(C)(C)C)=O.[NH:29]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:30]([C:39]([OH:41])=O)[CH2:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35].N[C@H](C(OC(C)(C)C)=O)C(C)C>>[NH:29]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:30]([C:39]([NH:17][C@H:18]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:41])[CH2:31][C:32](=[O:38])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37]

Komponenten

4

Edukt 3

HCID 1110824-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartateHCID 114626tert-Butyl valinateHCID 15674413HCID 15674413, Verbindung

Produkt 1

HCID 70050186HCID 70050186, Verbindung

Versuchsvorschrift

A diester such as H-Gly-Asp(OtBu)-Val-OtBu can be prepared by condensing Z-Asp(OtBu)-OH and H-Val-OtBu to give Z-Asp(OtBu)-Val-OtBu, hydrogenolyzing the latter, coupling the resulting H-Asp(OtBu)-Val-OtBu with Z-Gly-OSu to give Z-Gly-Asp(OtBu)-Val-OtBu and hydrogenolyzing the latter.

Quellen und Nachweise

ORD-Eintrag
ord-3c2bf62bcd4640fba426c57d9c71f519
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05663297

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