Ammonium fluoride → (4R)-13-hydroxy-11-methoxy-10-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4,5,6,7,9-hexahydro-1H-8,2,5-benzoxathiaazacycloundecine-6,9-dione

HRID 1377838

Reaktionsgleichung

Reaktionsgleichung von HRID 1377838
C[Si](C)(C(C)(C)C(C)C)[O:3][C:4]1[C:9]2[CH2:10][O:11][CH2:12][C@H:13]([C:21]3[O:25][N:24]=[C:23]([CH3:26])[N:22]=3)[NH:14][C:15](=[O:20])[CH2:16][S:17][C:18](=[O:19])[C:8]=2[C:7]([CH3:27])=[C:6]([O:28][CH3:29])[CH:5]=1.[F-].[NH4+]>CO.C(OCC)(=O)C>[OH:3][C:4]1[C:9]2[CH2:10][O:11][CH2:12][C@H:13]([C:21]3[O:25][N:24]=[C:23]([CH3:26])[N:22]=3)[NH:14][C:15](=[O:20])[CH2:16][S:17][C:18](=[O:19])[C:8]=2[C:7]([CH3:27])=[C:6]([O:28][CH3:29])[CH:5]=1

Komponenten

5

Edukt 2

HCID 25516Ammonium fluorideHCID 67712984(4R)-13-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-11-methoxy-10-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4,5,6,7,9-hexahydro-1H-8,2,5-benzoxathiaazacycloundecine-6,9-dione

Produkt 1

HCID 67712874(4R)-13-hydroxy-11-methoxy-10-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4,5,6,7,9-hexahydro-1H-8,2,5-benzoxathiaazacycloundecine-6,9-dioneAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 268 mg of (4R)-13-[dimethyl-(1,1,2-trimethylpropyl)-silanyloxy]-11-methoxy-10-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4,5,6,7,9-hexahydro-1H-8,2,5-benzoxathiaazacycloundecine-6,9-dione in 10 ml of methanol were added 100 mg of ammonium fluoride, and the mixture was stirred for 30 min at room temperature. The mixture was diluted with 50 ml of ethyl acetate and washed with 30 ml of water and with 30 ml of brine. The organic layer was dried over sodium sulfate and the solvent was evaporated in vacuo. The residue was dissolved in ethyl acetate, then hexane was added, and the white solid was isolated by filtration to give 178 mg of (4R)-13-hydroxy-11-methoxy-10-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4,5,6,7,9-hexahydro-1H-8,2,5-benzoxathiaazacycloundecine-6,9-dione as a white powder, m.p. 194°-196° C.

Aufarbeitung

  1. washwashed with 30 ml of water and with 30 ml of brine
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent was evaporated in vacuo
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. additionhexane was added
  6. customthe white solid was isolated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b157be9ee211413f993448828d88b921
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05665746

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