Sodium hydride → HCID 22911297, Verbindung

HRID 1378354Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1378354
[Cl:1][C:2]1[N:3]=[C:4]([O:16][CH3:17])[C:5]([NH:8][C:9](=[O:15])[O:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[N:6][CH:7]=1.[H-].[Na+].[I:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[S:27](Cl)(=[O:29])=[O:28]>CN(C)C=O>[Cl:1][C:2]1[N:3]=[C:4]([O:16][CH3:17])[C:5]([N:8]([C:9]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[O:15])[S:27]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[I:20])(=[O:29])=[O:28])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 6274002-Iodobenzene-1-sulfonyl chlorideHCID 22911289isobutyl N-(5-chloro-3-methoxypyrazin-2-yl)carbamate

Produkt 1

HCID 22911297HCID 22911297, VerbindungAusbeute 39 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Isobutyl N-(5-chloro-3-methoxypyrazin-2-yl)carbamate (3.34 g) was added to a stirred suspension of sodium hydride (60% dispersion in oil; 0.56 g) in dry N, N dimethylformamide (20 ml) at 0° C. The mixture was stirred at 0° C. for 1 hour and then a solution of 2-iodobenzenesulphonyl chloride (obtained as described in J Org Chem, 1977, 42, 3265) (4.68 g) was added. The mixture was stirred for 2 hours and then volatile material was removed by evaporation. The residue was dissolved in water (50 ml) and the solution was acidified with 20% aqueous citric acid and extracted with ethyl acetate (3×20 ml). The extracts were washed with water (25 ml) and saturated sodium chloride solution (25 ml) and dried (MgSO4). Volatile material was removed by evaporation and the residue was purified by gradient elution with 10-35% ethyl acetatesohexane through a silica gel Mega Bond Elut column to give N-(5-chloro-3-methoxypyrazin-2-yl)- N-(isobutoxycarbonyl)-2-iodobenzenesulphonamide (2.64 g); 1H NMR (d6 -DMSO): 0.67 (s, 6H), 1.65-1.8 (m, 1H), 3.9 (d, 2H), 4.0 (s, 3H), 3.9 (s, 3H), 7.4 (dd, 1H), 7.8 dd, 1H), 8.2 (d, 1H), 8.3 (d, 1H), 8.4 (s, 1H).

Aufarbeitung

  1. stirringThe mixture was stirred for 2 hours
  2. customvolatile material was removed by evaporation
  3. dissolutionThe residue was dissolved in water (50 ml)
  4. extractionextracted with ethyl acetate (3×20 ml)
  5. washThe extracts were washed with water (25 ml) and saturated sodium chloride solution (25 ml)
  6. dry with materialdried (MgSO4)
  7. customVolatile material was removed by evaporation
  8. customthe residue was purified by gradient elution with 10-35% ethyl acetatesohexane through a silica gel Mega Bond Elut column

Quellen und Nachweise

ORD-Eintrag
ord-f48c7ed371a14738864b8d941a394289
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05668137

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