Hydrochloric Acid → HCID 70207387, Verbindung

HRID 1378386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1378386
C([N:8]1[CH2:12][C@@H:11]([C:13]([F:16])([F:15])[F:14])[C@H:10]([CH2:17][OH:18])[CH2:9]1)C1C=CC=CC=1.[ClH:19]>C(O)C.[C].[Pd]>[ClH:19].[OH:18][CH2:17][C@H:10]1[C@H:11]([C:13]([F:16])([F:14])[F:15])[CH2:12][NH:8][CH2:9]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 70110585HCID 70110585, Verbindung

Produkt 1

HCID 70207387HCID 70207387, VerbindungAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 20 ml of ethanol, is dissolved 2.20 g (8.49 mmol) of trans-1-benzyl-3-hydroxymethyl-4-trifluoromethylpyrrolidine, and 1 ml of conc-hydrochloric acid is added to the solution. A hydrogenation is performed by adding 440 mg of 10% palladium carbon to the above solution at 40° C. and 1 atmospheric pressure. Four hours later, the catalyzer was removed by filtration, and the filtrate was concentrated under reduced pressure to give 1.74 g of the objective substance as a colorless powder (yield 99.7%).

Aufarbeitung

  1. additionis added to the solution
  2. customFour hours later, the catalyzer was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-70d3270a4499409d8a56fd43262c9e31
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05668147

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