4-(4-Ethylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride → 4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]phenyl}benzamide

HRID 13785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13785
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[NH:9][C:10]1[CH:15]=[C:14]([C:16]2[CH:17]=[N:18][CH:19]=[N:20][CH:21]=2)[CH:13]=[CH:12][N:11]=1.Cl.Cl.[CH2:24]([N:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]2[CH:41]=[CH:40][C:36]([C:37](Cl)=[O:38])=[CH:35][C:34]=2[C:42]([F:45])([F:44])[F:43])[CH2:28][CH2:27]1)[CH3:25]>>[CH2:24]([N:26]1[CH2:27][CH2:28][N:29]([CH2:32][C:33]2[CH:41]=[CH:40][C:36]([C:37]([NH:6][C:5]3[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([NH:9][C:10]4[CH:15]=[C:14]([C:16]5[CH:17]=[N:18][CH:19]=[N:20][CH:21]=5)[CH:13]=[CH:12][N:11]=4)[CH:4]=3)=[O:38])=[CH:35][C:34]=2[C:42]([F:45])([F:43])[F:44])[CH2:30][CH2:31]1)[CH3:25]

Komponenten

3

Edukt 2

HCID 231458504-(4-Ethylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochlorideHCID 231459624-Methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]aniline

Produkt 1

HCID 112845834-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]phenyl}benzamide

Versuchsvorschrift

This compound was prepared in the same manner as in Example 1, except that 4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]aniline (Reference Example 22) and 4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride (Reference Example 5) were used, and that the resulting crude crystals were washed with ethyl acetate.

Aufarbeitung

  1. washthat the resulting crude crystals were washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-6e517765710c4ce2aff2f2aa059c94ef
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728131B2

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