HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethyl Phosphate → Fludarabine Phosphate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethyl Phosphate | HCID 6535 | — |
| Edukt | Trimethyl Phosphate | HCID 10541 | — |
| Edukt | Phosphorus oxychloride | HCID 24813 | — |
| Edukt | Fludarabine | HCID 657237 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | Fludarabine Phosphate | HCID 30751 | — |
Reaktionsschritte
Phosphorylation: The product from step (e) is mixed with phosphorous oxychloride in an alkyl phosphate such as triethylphosphate, or trimethylphosphate, followed by hydrolysis in water to yield the prodrug 9-β-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate or fludarabine phosphate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05668270 |
| Quelldatensatz | uspto-grants-1997_09 |
| ORD ID | ord-72a99bafbb514bbab605ba8061710d21 |
| Quellennotiz | uspto-grants-1997_09 |