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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1378841Erstellt: 26. Oktober 2026

Tetrabutylammonium Fluoride → 2,6-Dipropyl-4-(2-hydroxyethyl)phenol

https://huagongshe.com/reaction/1378841

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTetrabutylammonium FluorideHCID 2724141—
Eduktt-Butyldimethylsilyloxy-2,6-dipropyl-4-(2-hydroxyethyl)-benzeneHCID 19080442—
LösungsmittelTetrahydrofuranHCID 8028—
Produkt2,6-Dipropyl-4-(2-hydroxyethyl)phenolHCID 19080373170,6%

Reaktionsschritte

To a solution of 1.0 g (2.98 mmol) of the product of Step C in 3.0 mL of THF was added 3.57 mL (3.57 mmol) of 1.0N solution of tetrabutylammonium fluoride in THF. After 15 minutes TLC indicated that the reaction was complete. The reaction mixture was concentrated and then purified by flash chromatography (silica gel, hexane/ethyl acetate 3:1) to give 1.13 g of the title compound.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS05668176
Quelldatensatzuspto-grants-1997_09
ORD IDord-2ec0b3648f4e4ce9aa1b431cbce5977c
Quellennotizuspto-grants-1997_09