3-(3-Bromo-4-fluorophenyl)-2-propenoic acid → (E)-8-(3-Bromo-4-fluorostyryl)-1,3-diethylxanthine

Beteiligte Stoffe

Reaktionsschritte

Substantially the same procedure as in Reference Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 4.08 g (16.7 mmol) of 3-bromo-4-fluorocinnamic acid. The resulting crude crystals were recrystallized from dioxane to give 2.90 g (yield 47%) of Compound k as a pale yellow powder.

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