Ammonia → HCID 22909360, Verbindung

HRID 1379041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1379041
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]2[C:30](=[O:31])[C:29]3[CH:32]=[CH:33][CH:34]=[C:27]4[C:28]=3[C:23](=[CH:24][CH:25]=[CH:26]4)[C:22]2=[O:35])[CH2:15][CH2:14]1)(O)=[O:2].CS([O-])(=O)=O.ClC1C=CC=C[N+:43]=1C.N>CN1CCCC1>[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]2[C:30](=[O:31])[C:29]3[CH:32]=[CH:33][CH:34]=[C:27]4[C:28]=3[C:23](=[CH:24][CH:25]=[CH:26]4)[C:22]2=[O:35])[CH2:15][CH2:14]1)(=[O:2])[NH2:43]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 9834448HCID 9834448, VerbindungHCID 22909437HCID 22909437, Verbindung

Produkt 1

HCID 22909360HCID 22909360, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 84541-MethylpyrrolidineLösungsmittel

Versuchsvorschrift

2.1 g of 2-[2-(4-(5-carboxy-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione are suspended in 100 ml of N-methylpyrrolidine. 3.2 g of 2-chloro-1-methylpyridinium methanesulfonate are then added and the mixture is stirred at room temperature for 12 hours. Dried NH3 gas is passed into the resulting solution until it is saturated and the mixture is stirred again for 10 hours. Customary working up gives 2-[2-(4-(5-carbamoyl-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione.

Aufarbeitung

  1. stirringthe mixture is stirred again for 10 hours

Quellen und Nachweise

ORD-Eintrag
ord-33588121d25c4338aeaf7bee4ee792bb
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05670511

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