1-(4-Chlorophenyl)-2-butyn-1-ol → (Z)-1-(4-chlorophenyl)-2-buten-1-ol

HRID 1380346

Reaktionsgleichung

Reaktionsgleichung von HRID 1380346
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])/[CH:9]=[CH:10]\[CH3:11])=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 201883391-(4-Chlorophenyl)-2-butyn-1-ol

Produkt 1

HCID 67901371(Z)-1-(4-chlorophenyl)-2-buten-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 131709914Lindlars catalystKatalysator

Versuchsvorschrift

Under nitrogen, hydrogenate a mixture of 10 g (0.055 mole) of 1-(4-chlorophenyl)-2-butyn-1-ol and 0.6 g Lindlar catalyst. Following the reaction via NMR the reaction is complete in about two days. The hydrogenation is stopped and the reaction stirred under N2 at room temperature overnight. Filter off the catalysts, wash with methylene chloride combine the filtrate and evaporate to yield the title compound.

Aufarbeitung

  1. customthe reaction via NMR the reaction
  2. filtrationFilter off the catalysts
  3. washwash with methylene chloride
  4. customevaporate

Quellen und Nachweise

ORD-Eintrag
ord-413af3631eaf47fdb58ab7913b111ccb
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04581370

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