Benzenesulfonyl chloride → N-(2-Amino-2-methylpropyl)benzenesulfonamide

HRID 1380591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380591
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].[C:7]1([S:13](Cl)(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.N1C=CC=CC=1>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][S:13]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:15])=[O:14]

Komponenten

5

Edukt 2

HCID 7369Benzenesulfonyl chlorideHCID 131282-Methylpropylenediamine

Produkt 1

HCID 23046101N-(2-Amino-2-methylpropyl)benzenesulfonamideAusbeute 79,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a mixture of 14.97 g (0.169 mol) of 1,2-diamino-2-methylpropane in 300 ml of chloroform and 80 ml pyridine was added 10 g (0.057 mol) of benzenesulfonyl cloride at 0° C. The reaction mixture was stirred at 0° C. for 30 minutes and allowed to reach room temperature. The mixture was evaporated to dryness in vacuo and the residue was partitioned between water and chloroform. Evaporation of the chloroform gave 10.3 g (79%) of semisolid. The product was identified by NMR and IR spectroscopy and elemental analysis.

Aufarbeitung

  1. customto reach room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customthe residue was partitioned between water and chloroform
  4. customEvaporation of the chloroform

Quellen und Nachweise

ORD-Eintrag
ord-3582140b21024839b67edee648677a1f
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04582855

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