4,5-Diaminopyrimidine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

HRID 1380720

Reaktionsgleichung

Reaktionsgleichung von HRID 1380720
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16][C:17]1[C:22]([NH2:23])=[CH:21][N:20]=[CH:19][N:18]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[N:16]=[C:17]2[C:22]([NH:23][CH:19]=[N:18]2)=[CH:21][N:20]=1

Komponenten

3

Edukt 2

HCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

Produkt 1

HCID 201845292-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

Versuchsvorschrift

Prepared analogously to Example C from 2.5 gm of 2-methoxy-4-chlorosulfonyl benzoic acid and 2.4 gm of 4,5-diamino-pyrimidine (crystalline product obtained from dihydorchloride and 1 mol of common salt) by refluxing for eight hours. The solid crude product was processed further without any purification.

Aufarbeitung

  1. temperatureby refluxing for eight hours
  2. customThe solid crude product was processed further without any purification

Quellen und Nachweise

ORD-Eintrag
ord-6d842c7706d44ef9bc1746be111d8ca0
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04582837

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