Methyl Isocyanate → HCID 20184542, Verbindung

HRID 1380764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380764
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1.[CH3:24][N:25]=[C:26]=[O:27]>O1CCCC1>[CH3:24][NH:25][C:26]([NH:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1)=[O:27]

Komponenten

4

Edukt 2

HCID 12228Methyl IsocyanateHCID 20184521HCID 20184521, Verbindung

Produkt 1

HCID 20184542HCID 20184542, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

One gram (3.0 mmol) of 5-amino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was dissolved in 30 ml of pure tetrahydrofuran, 2.0 ml of methylisocyanate were added, and the mixture was refluxed. After 15 minutes that solvent and any excess methylisocyanate were evaporated off in vacuo, and the residue obtained was chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol).

Aufarbeitung

  1. temperaturethe mixture was refluxed
  2. customany excess methylisocyanate were evaporated off in vacuo
  3. customthe residue obtained
  4. customwas chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol)

Quellen und Nachweise

ORD-Eintrag
ord-3387be441d6e41eb8e6e0f156a070559
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04582837

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