Methyl 4-chloroacetoacetate → HCID 178494252, Verbindung

HRID 1380848Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380848
Cl.[CH3:2][O:3][C:4](=[NH:6])[NH2:5].[Cl:7][CH2:8][C:9](=O)[CH2:10][C:11](OC)=[O:12]>>[Cl:7][CH2:8][C:9]1[CH:10]=[C:11]([OH:12])[N:5]=[C:4]([O:3][CH3:2])[N:6]=1

Komponenten

3

Edukt 2

HCID 36240Methyl 4-chloroacetoacetateHCID 3083899Carbamimidic acid, methyl ester, hydrochloride (1:1)

Produkt 1

HCID 178494252HCID 178494252, Verbindung

Versuchsvorschrift

Analogously to the process described in Example 113, O-methylisourea hydrochloride or hydrosulphate is reacted with methyl 4-chloroacetoacetate in order to produce 4-chloromethyl-6-hydroxy-2-methoxy-pyrimidine, m.p. 154°-155° C., which is required as the starting material in Examples 68, 69 and 77.

Quellen und Nachweise

ORD-Eintrag
ord-a4028b126a79412ba20df64ffc2d5794
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04584295

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