Ethyl 2,4-dinitro-5-fluorophenoxyacetate → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

HRID 1381643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1381643
[N+:1]([C:4]1[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([F:20])=[CH:13][C:5]=1[O:6][CH2:7][C:8](OCC)=[O:9])([O-])=O.[H][H]>C(O)C.[C].[Pd]>[F:20][C:14]1[C:15]([NH2:17])=[CH:16][C:4]2[NH:1][C:8](=[O:9])[CH2:7][O:6][C:5]=2[CH:13]=1

Komponenten

5

Edukt 2

HCID 14423667Ethyl 2,4-dinitro-5-fluorophenoxyacetateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 103133897-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-oneAusbeute 82,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of ethyl 2,4-dinitro-5-fluorophenoxyacetate (1.3 g) and 5% palladium-carbon (0.35 g) in ethanol (30 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 600 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.68 g; yield, 82.8%).

Aufarbeitung

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-92e17dc7626b4ac49c68a069184d8e04
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04803270

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