Potassium Carbonate → Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

HRID 1381998

Reaktionsgleichung

Reaktionsgleichung von HRID 1381998
Cl[C:2]1[C:24]([N+:25]([O-:27])=[O:26])=[C:23]([Cl:28])[C:22]([F:29])=[CH:21][C:3]=1[C:4]([C:6](=[CH:12][NH:13]CCC(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:28][C:23]1[C:24]([N+:25]([O-:27])=[O:26])=[C:2]2[C:3]([C:4]([OH:5])=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:12]=[N:13]2)=[CH:21][C:22]=1[F:29]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 178472018HCID 178472018, Verbindung

Produkt 1

HCID 178469671Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

52 g of the product from Example 4 and 18.5 g of K2CO3 are heated at 140° C. for 4 hours in 160 ml of DMF. The mixture is subsequently poured onto ice and acidified, and the precipitated solid is isolated. It is dried and recrystallized from glycol methyl ether acetate. Yield: 35.8 g, melting point: 226°-8° C. (decomposes).

Aufarbeitung

  1. additionThe mixture is subsequently poured onto ice
  2. customthe precipitated solid is isolated
  3. customIt is dried
  4. customrecrystallized from glycol methyl ether acetate

Quellen und Nachweise

ORD-Eintrag
ord-f6a0323c7d3442f382cb357069b2dd59
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04804760

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