2-Bromopropanoyl chloride → HCID 15611036, Verbindung

HRID 1382159

Reaktionsgleichung

Reaktionsgleichung von HRID 1382159
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH2:14])(=[O:13])=[O:12].[Br:15][CH:16]([CH3:20])[C:17](Cl)=[O:18]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH:14][C:17](=[O:18])[CH:16]([Br:15])[CH3:20])(=[O:13])=[O:12]

Komponenten

3

Edukt 2

HCID 979802-Bromopropanoyl chlorideHCID 209044Benzenesulfonamide, 2,5-dimethoxy-

Produkt 1

HCID 15611036HCID 15611036, Verbindung

Versuchsvorschrift

A stirred mixture of 7.0 g (0.032 mole) of 2,5-dimethoxyphenylsulfonamide in 10 mL of 2-bromopropionyl chloride was heated at reflux for 40 minutes then allowed to cool to room temperature. The resultant solution was poured into petroleum ether. Crystals formed after scratching the sides of the flask and were collected by filtration. The filter cake was washed four times with fresh petroleum ether to yield 10.3 g of N-(2,5-dimethoxyphenylsulfonyl)-2-bromopropionamide (mp 116°-118° C.).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 40 minutes
  3. customCrystals formed
  4. filtrationwere collected by filtration
  5. washThe filter cake was washed four times with fresh petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-5a22b3ebdf9b41f48650b929e3982123
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04806145

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