HCID 178471921, Verbindung → 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone

HRID 1382267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1382267
[CH:1]1([C:7]([C:9](=[CH:15][NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[C:10]([O:12]CC)=O)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH:1]1([C:7]([C:9]2[C:10](=[O:12])[C:22]3[C:17](=[C:18]([O:23][CH3:24])[CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

3

Edukt 1

HCID 178471921HCID 178471921, Verbindung

Produkt 1

HCID 100167833-cyclohexylcarbonyl-8-methoxy-4(1H)-quinoloneAusbeute 35,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

Ethyl 2-cyclohexylcarbonyl-3-(2-methoxyphenylamino)acrylate (20 g, 0.06 mol) was added in portions to boiling diphenyl ether (200 ml) and the mixture was heated under reflux for 1.5 hours. When cool, the mixture was diluted with petroleum ether and allowed to crystallise overnight to give 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone (6.0 g, 35.2%), m.p. 168°-70° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. temperatureWhen cool
  4. customto crystallise overnight

Quellen und Nachweise

ORD-Eintrag
ord-21a8ca2d744a4e3a93dc2a7fa5099ca2
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04806549

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