HCID 178471921, Verbindung → 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone

HRID 1382319Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1382319
[CH:1]1([C:7]([C:9](=[CH:15][NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[C:10]([O:12]CC)=O)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH:1]1([C:7]([C:9]2[C:10](=[O:12])[C:22]3[C:17](=[C:18]([O:23][CH3:24])[CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

3

Edukt 1

HCID 178471921HCID 178471921, Verbindung

Produkt 1

HCID 100167833-cyclohexylcarbonyl-8-methoxy-4(1H)-quinoloneAusbeute 35,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

Ethyl 2-cyclohexylcarbonyl-3-(2-methoxyphenylamino)acrylate (20 g, 0.06 mol) was added in portions to boiling diphenyl ether (200 ml) and the mixture was heated under reflux for 1.5 hours. When cool, the mixture was diluted with petroleum ether and allowed to crystallise overnight to give 3-cyclohexylcarbonyl-8-methoxy-4(1H)-quinolone (6.0 g, 35.2%), m.p. 168°-70° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. temperatureWhen cool
  4. customto crystallise overnight

Quellen und Nachweise

ORD-Eintrag
ord-0d22e12c6226428f87227f7bf6bda92e
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04806550

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