1,1-Dibutoxytrimethylamine → HCID 178481358, Verbindung

HRID 1382721

Reaktionsgleichung

Reaktionsgleichung von HRID 1382721
[C:1]([C:4]1[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=1[NH2:10])(=[O:3])[CH3:2].[CH2:15](OC(OCCCC)N(C)C)CCC>CN(C=O)C>[OH:3][C:1]1[C:4]2[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=2[N:10]=[CH:15][CH:2]=1

Komponenten

4

Edukt 2

HCID 876831,1-DibutoxytrimethylamineHCID 3200235-Acetyl-6-amino-1,3-dimethyluracil

Produkt 1

HCID 178481358HCID 178481358, VerbindungAusbeute 70,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

0.8 g of 5-acetyl-6-amino-1,3-dimethyluracil was dissolved in DMF and 4 ml of dimethylformamide dibutylacetal was added thereto. The solution was heated for 8 hr at 80° C. and distilled under reduced pressure. After purification by silica gel column chromatography, the crude product was recrystallized from ethanol to give 0.59 g of 5-hydroxy1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 14).

Aufarbeitung

  1. distillationdistilled under reduced pressure
  2. customAfter purification by silica gel column chromatography
  3. customthe crude product was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-303b74edd28c4f0da0843227cddd9aa1
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04808587

Verknüpfte Notizen

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