m-Chloroperbenzoic acid → 2-Sulfamoylfuro[3,2-c]pyridine-5-oxide

HRID 1382986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1382986
[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].ClC1C=CC=C(C(OO)=[O:22])C=1>CO.C(OCC)(=O)C>[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N+:9]([O-:22])=[CH:8][C:7]=2[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

Komponenten

5

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 14372124Furo[3,2-c]pyridine-2-sulfonamide

Produkt 1

HCID 143721302-Sulfamoylfuro[3,2-c]pyridine-5-oxideAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a warm (40° C.) solution of 2-sulfamoylfuro[3,2-c]pyridine (2.68 g, 13.5 mmol) in methanol (30 ml) and ethyl acetate (10 ml) was added dropwise a solution of m-chloroperbenzoic acid (3.22 g, 15 mmol) in ethyl acetate (13 ml). The reaction mixture was stirred for 18 hours as product precipitated. The pure product was collected by filtration and crystallized from hot dimethyl sulfoxide by dilution with ethanol to give 2.4 g (83% yield), m.p. 247°-248° C.

Aufarbeitung

  1. customprecipitated
  2. filtrationThe pure product was collected by filtration
  3. customcrystallized from hot dimethyl sulfoxide by dilution with ethanol
  4. customto give 2.4 g (83% yield), m.p. 247°-248° C.

Quellen und Nachweise

ORD-Eintrag
ord-9e64870d66ed47cd91d6e226ac95e6d4
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04808595

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