3-[2-(Quinolin-2-yl)ethenyl]benzaldehyde → HCID 22617026, Verbindung

HRID 1383385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1383385
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[CH:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[O:17]>[C].[Pd]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[O:17]

Komponenten

3

Edukt 1

HCID 538887303-[2-(Quinolin-2-yl)ethenyl]benzaldehyde

Produkt 1

HCID 22617026HCID 22617026, VerbindungAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418390HCID 178418390, VerbindungLösungsmittel

Versuchsvorschrift

5.5 g (21.2 mmol) of 3-[2-(2-quinolyl)ethenyl]benzaldehyde was dissolved in 500 ml and hydrogenated in the presence of 1.1 g of 10% palladium carbon at atmospheric pressure at room temperature for 10 hours under stirring. The 10% palladium carbon was filtered out through celite, and the filtrate was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=9:1) to give 2.8 g (10.7 mmol) of the title compound in a yield of 51%.

Aufarbeitung

  1. filtrationThe 10% palladium carbon was filtered out through celite
  2. customthe filtrate was evaporated in vacuo
  3. customThe residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=9:1)

Quellen und Nachweise

ORD-Eintrag
ord-806febedcc4142b797587d952c7b8092
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06255321B1

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