Hydrochloric Acid → 4-(2-Fluorophenyl)-4-hydroxy-cyclohexanone

HRID 1383769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1383769
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([OH:18])[CH2:17][CH2:16][C:11]2(OCC[O:12]2)[CH2:10][CH2:9]1.Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([OH:18])[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 211876398-(2-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Produkt 1

HCID 211876834-(2-Fluorophenyl)-4-hydroxy-cyclohexanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 8-(2-fluorophenyl)-1,4-dioxa-spiro[4.5]decan-8-ol (5.8 g, 23 mmol) in dioxane (100 mL), cooled to 0° C. was added hydrogen chloride (1M in water, 75 ml, 75 mmol). The reaction mixture was stirred for 2 hour at room temperature, extracted with ethyl ether (2×200 mL) and washed with saturated bicarbonate solution, water and brine. Drying and solvent evaporation gave 4-(2-Fluorophenyl)-4-hydroxy-cyclohexanone in quantitative yield.

Aufarbeitung

  1. extractionextracted with ethyl ether (2×200 mL)
  2. washwashed with saturated bicarbonate solution, water and brine
  3. customDrying
  4. customsolvent evaporation

Quellen und Nachweise

ORD-Eintrag
ord-4c1e19a4b7a54b7e90afa8726f40b7cf
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06255315B1

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