Hydrogen Bromide → Ethyl 2-benzyl-4-bromobutanoate

HRID 1383960

Reaktionsgleichung

Reaktionsgleichung von HRID 1383960
[CH2:1]([CH:8]1[CH2:13][CH2:12][O:11][C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:14].[CH2:15](O)[CH3:16]>>[CH2:1]([CH:8]([CH2:13][CH2:12][Br:14])[C:9]([O:11][CH2:15][CH3:16])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 5627582-Benzyl-butyrolactone

Produkt 1

HCID 21188482Ethyl 2-benzyl-4-bromobutanoate

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

In absolute ethanol (78 ml), α-benzyl-γ-butyrolactone (14 g, 80 mmol) was added and then saturated for thirty minutes with gaseous hydrogen bromide, maintaining the temperature below 50° C. The reaction was then heated to 45° C. and stirred at this temperature for 16 hours. The solution was concentrated under reduced pressure and the resulting oil was taken into ethyl acetate (500 ml), washed once with water, and then dried over magnesium sulfate. The solvents were removed in vacuo to yield 15.13 grams of tan oil.

Aufarbeitung

  1. temperaturemaintaining the temperature below 50° C
  2. concentrationThe solution was concentrated under reduced pressure
  3. washwashed once with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a94ccb2a582547f6bf1e5a7945b8f79f
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06255494B1

Verknüpfte Notizen

Wird geladen…