Hydrochloric Acid → 4-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

HRID 1384345Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1384345
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[OH:20])[CH:17]=3)[N:12]=[C:11]([O:34]C)[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([OH:20])[C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[CH:17]=3)[NH:12][C:11](=[O:34])[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22465439[4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol

Produkt 1

HCID 224654294-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Following the same procedure as described in example 1F, [4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol (886 mg, 1.68 mmol) was treated with HCl in aqueous THF to yield the title compound of 16D. It was directly used for the next reaction without further purification.

Quellen und Nachweise

ORD-Eintrag
ord-dddc8a861e31490c9d3dde946a0780d6
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06258824B1

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