3-Chloro-2-(phenylsulfonyl)-5-(trifluoromethyl)pyridine → 2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:3](S(C2C=CC=CC=2)(=O)=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:21][C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25]([Mg]Br)=[C:24]([F:32])[CH:23]=1>C1COCC1>[Cl:21][C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25]([C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:5][N:4]=2)=[C:24]([F:32])[CH:23]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-Chloro-2-phenylsulfonyl-5-trifluoromethylpyridine was stirred with 4-chloro-2-fluoro-5-methoxyphenylmagnesium bromide for 2.5 hours at room temperature in THF. Working-up by distillation gave the coupling product 2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine in a yield of 84%, which is outstanding.