2-Fluoro-5-(hydroxymethyl)benzonitrile → 2-Fluoro-5-formylbenzonitrile

HRID 1386050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386050
[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH2:6][OH:7])#[N:2]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[F:11])[CH:6]=[O:7])#[N:2]

Komponenten

4

Edukt 1

HCID 27739342-Fluoro-5-(hydroxymethyl)benzonitrile

Produkt 1

HCID 27695822-Fluoro-5-formylbenzonitrileAusbeute 54,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of the product from Example 82B (0.40 g, 2.6 mmol) in chloroform (50 mL) was treated with manganese dioxide (0.55 g, 7.8 mmol), stirred at room temperature overnight, filtered, solvent evaporated and the residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1) to provide 0.21 g 3-cyano-4-fluorobenzaldehyde.

Aufarbeitung

  1. filtrationfiltered
  2. customsolvent evaporated
  3. customthe residue flash chromatographed over silica gel eluting with ethyl acetate:hexane (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-eca09c83a5364db3b29d773169eb1b7d
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265417B1

Notizen zur Reaktion

Wird geladen…