Potassium Iodide → HCID 21717342, Verbindung

HRID 1386076Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386076
[NH2:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18]Br)[CH3:15].[I-].[K+].C([O-])([O-])=O.[Na+].[Na+]>C(COC)OC>[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18][NH:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH3:15]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 21717327HCID 21717327, VerbindungHCID 226726328-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine

Produkt 1

HCID 21717342HCID 21717342, VerbindungAusbeute 29 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

8-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine (0.38 g, 2.16 mmol) and 2-ethyl-4-fluoro-6-methylbenzylbromide (0.50 g, 2.16 mmol) were dissolved in 10 ml dimethoxyethane. Potassium iodide (0.2 g, 1.2 mmol) and Na2CO3 (0.4 g, 3.8 mmol) were added and the mixture was refluxed for 6 hours. The solvent was evaporated and the residue was purified by column chromatography on silica gel using a mixture of methylene chloride and ethyl acetate (60:40) as eluent. 203 mg (29%) of the title compound was obtained.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 6 hours
  2. customThe solvent was evaporated
  3. customthe residue was purified by column chromatography on silica gel using
  4. additiona mixture of methylene chloride and ethyl acetate (60:40) as eluent

Quellen und Nachweise

ORD-Eintrag
ord-14bc3e2bfc4f43fc9ca11e04c3ae6f34
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265415B1

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