2-Butanone, 3-bromo- → 6-Bromo-2,3-dimethylimidazo[1,2-a]pyridin-8-ylamine

HRID 1386085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386085
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.Br[CH:11]([CH3:15])[C:12](=O)[CH3:13]>C(O)C>[NH2:8][C:7]1[C:2]2[N:3]([C:11]([CH3:15])=[C:12]([CH3:13])[N:1]=2)[CH:4]=[C:5]([Br:9])[CH:6]=1

Komponenten

4

Edukt 2

HCID 131422-Butanone, 3-bromo-HCID 6911565-Bromopyridine-2,3-diamine

Produkt 1

HCID 217173556-Bromo-2,3-dimethylimidazo[1,2-a]pyridin-8-ylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2,3-diamino-5-bromopyridine (4.0 g, 21.29 mmol) and 3-bromo-2-butanone (3.7 g, 24.48 mmol) in ethanol (40 ml) was refluxed overnight. After cooling to room temperature, the crystalline product was filtered and washed with ethanol and ether. The crystals were dissolved in methylene chloride and neutralized by aqueous NaHCO3. The organic layer was separated, dried over Na2SO4 and evaporated in vacuo. Yield 2.3 g.

Aufarbeitung

  1. filtrationthe crystalline product was filtered
  2. washwashed with ethanol and ether
  3. dissolutionThe crystals were dissolved in methylene chloride
  4. customThe organic layer was separated
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1c283dadd08b4644ab0a2cb72134620a
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265415B1

Notizen zur Reaktion

Wird geladen…