Trifluoroacetic acid → HCID 86757209, Verbindung
Reaktionsgleichung
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([C:28]([O:30][CH2:31][CH3:32])=[O:29])([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:17]1([CH2:16][C:15]([C:28]([O:30][CH2:31][CH3:32])=[O:29])([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 520 mg (1.16 mmol) of 1-(t-butoxycarbonyl)-4-(3-phenyl-2,2-bis(carboethoxy)propyl)piperidine (from EXAMPLE 32, Step C) in 5 mL of CH2Cl2 at 0° C. was treated with 5 mL of TFA. The resulting mixture was warmed to rt and stirred for 1.5 h. The reaction was concentrated and triturated with ether. The solid that formed was filtered and dried to afford 617 mg of 4-(3-phenyl-2,2-bis(carboethoxy) propyl)piperidine.TFA.