Potassium Carbonate → HCID 53804942, Verbindung

HRID 1386829

Reaktionsgleichung

Reaktionsgleichung von HRID 1386829
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1.[I:17][CH2:18][CH2:19][CH2:20]I.C(=O)([O-])[O-].[K+].[K+]>>[I:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 11430Potassium CarbonateHCID 123141,3-DiiodopropaneHCID 19439747N-(4-Hydroxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide

Produkt 1

HCID 53804942HCID 53804942, Verbindung

Versuchsvorschrift

6.5 g (0.03 mol) of 5-methylisoxazole-4-carboxylic acid (4-hydroxyphenyl)amide are dissolved in 57 ml (0.5 mol) of 1,3-diiodopropane and 26.2 g (0.19 mol) of finely ground potassium carbonate are added with intensive stirring. The reaction is complete after approximately 4 h. Working up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid. The yield of the process was 6.7 g.

Aufarbeitung

  1. filtrationWorking up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid

Quellen und Nachweise

ORD-Eintrag
ord-5e2b4484594241b88abc525754992300
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265588B1

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