Methanesulfonic Acid → 2-Dimethylamino-5-fluoro-6-methoxybenzo[b]thiophene

HRID 1387044Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1387044
[CH3:1][N:2]([CH3:16])[C:3](=[S:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([F:13])[C:6]=1O.CS(O)(=O)=O>C(Cl)Cl>[CH3:1][N:2]([CH3:16])[C:3]1[S:15][C:10]2[CH:9]=[C:8]([O:11][CH3:12])[C:7]([F:13])=[CH:6][C:5]=2[CH:4]=1

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 21182765N,N-dimethyl-3-fluoro-4-methoxy-2-hydroxyphenylthioacetamide

Produkt 1

HCID 107755692-Dimethylamino-5-fluoro-6-methoxybenzo[b]thiopheneAusbeute 139,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 16.6 g (68.2 mmol) of N,N-dimethyl-3-fluoro-4-methoxy-2-hydroxyphenylthioacetamide (Part A) in 400 mL of CH2Cl2 was treated with 22.0 mL (339.0 mmol) of MeSO3H in a dropwise manner. The reaction was stirred at room temperature for 4 h, was cooled to 0° C., and was quenched by the careful addition of 500 mL of saturated aqueous NaHCO3. The two layers were separated and the aqueous layer was extracted with EtOAc (5×200 mL). The combined organic layers were washed with 500 mL of saturated aqueous NaHCO3 and 500 mL of H2O, dried over Na2SO4, and filitered. Evaporation of the solvent in vacuo afforded 21.4 g of an oil which was purified by flash chormatography (SiO2; gradient of 10% then 20% EtOAc in hexanes) to give 2.87 g (12.7 mmol; 19%) of the title compound as a light pink solid

Aufarbeitung

  1. temperaturewas cooled to 0° C.
  2. customwas quenched by the careful addition of 500 mL of saturated aqueous NaHCO3
  3. customThe two layers were separated
  4. extractionthe aqueous layer was extracted with EtOAc (5×200 mL)
  5. washThe combined organic layers were washed with 500 mL of saturated aqueous NaHCO3 and 500 mL of H2O
  6. dry with materialdried over Na2SO4
  7. customEvaporation of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ddf33b6878fa43b3ba7bc1698d873b2f
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265575B1

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