Glyceraldehyde → Ethyl acetate methanol ammonium hydroxide

Beteiligte Stoffe

Reaktionsschritte

3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (113 mg) was dissolved in dichloromethane:methanol (2:1, 6.0 mL), treated with glyceraldehyde (25 mg) and sodium triacetoxyborohydride (60 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated, and column chromatography with NH4OH:MeOH:EtOAc (3:7:90) afforded the product (56 mg).

Herkunft & Nachweise