Hydrochloric Acid → 4-Biphenylylacetic acid methyl ester

HRID 1387292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1387292
[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.Cl.[CH3:18]O>>[CH3:18][O:9][C:8](=[O:10])[CH2:7][C:4]1[CH:3]=[CH:2][C:1]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3332Felbinac

Produkt 1

HCID 30808634-Biphenylylacetic acid methyl esterAusbeute 98 %

Versuchsvorschrift

To a solution of 4-biphenylacetic acid (10 g, 47 mmol) in methanol (150 mL) was added concentrated HCl (3 mL). The mixture was heated under reflux for 16 hours, cooled to rt, and the solvent was evaporated. Chromatography of the residue over silica gel (petroleum ether followed by ethyl acetate/petroleum ether 1/4) gave 4-biphenylacetic acid methyl ester (10.4 g, 98%).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 16 hours
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d2a8faec8cdb4e2785435497ae8ba8bf
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06268365B1

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