Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Amlodipine | HCID 2162 | — |
| Edukt | Felodipine | HCID 3333 | — |
| Edukt | Isradipine | HCID 3784 | — |
| Edukt | Nilvadipine | HCID 4494 | — |
| Edukt | Nimodipine | HCID 4497 | — |
| Edukt | Nisoldipine | HCID 4499 | — |
| Edukt | Nitrendipine | HCID 4507 | — |
| Edukt | Flordipine | HCID 53699 | — |
| Edukt | Niludipine | HCID 89767 | — |
| Produkt | Nicardipine | HCID 4474 | — |
Reaktionsschritte
Nitrendipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-phyridindicarboxylic acid ethyl methyl ester); Nisoldipine (1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester); Felodipine (4-(2,3-dichlorophenyl)-1,4dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester); Nimodipine (1,4-dihydro-2,6dimethyl-4-(3-nitrophenyl-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester); Niludipine; Amlodipine (2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester); Flordipine; Ryosidine; FR 7534; Nilvadipine (FR 34235, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester); PY 108-068; and Isradipine (PN 200-110, 4-(4-benxofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methyl-ethyl ester).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06268377B1 |
|---|
| Quelldatensatz | uspto-grants-2001_07 |
|---|
| ORD ID | ord-38bb1e0ddabe4432bff2c94bdb1b4d5e |
|---|
| Quellennotiz | uspto-grants-2001_07 |
|---|
