1-Methylhomopiperazine → 1H-Benzimidazole, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1-(2-phenoxyethyl)-, (E)-2-butenedioate (1:2)
Reaktionsgleichung
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[N:3]=1.[CH3:20][N:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[O:9]([CH2:8][CH2:7][N:6]1[C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[N:3]=[C:2]1[N:24]1[CH2:25][CH2:26][CH2:27][N:21]([CH3:20])[CH2:22][CH2:23]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1Komponenten
4
Versuchsvorschrift
In the same manner as described in Example 1 using 2-chloro-1-[2-(phenoxy)ethyl)benzimidazole (4.00 g), N-methylhomopiperazine (4.00 g) and fumaric acid (2.65 g), there are obtained crude crystals, which are recrystallized from ethanol to give 1-[2-(phenoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate (3.50 g) as colorless needles, m.p. 167°-168° C.