Barium → 4-(1H-Imidazol-2-yl)-pyridine

HRID 1388380

Reaktionsgleichung

Reaktionsgleichung von HRID 1388380
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)=[CH:3][CH:2]=1.[Ba]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

Komponenten

4

Edukt 2

HCID 5355457BariumHCID 111593874-(4,5-dihydro-1H-imidazol-2-yl)pyridine

Produkt 1

HCID 3168174-(1H-Imidazol-2-yl)-pyridineAusbeute 68,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(4-pyridyl)-imidazoline (7.0 g, 0.047 M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered through diatomaceous earth
  2. washwashed with methylene chloride
  3. concentrationThe combined filtrates were concentrated
  4. customcrystallized from ethylacetate-petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-176e8998b12847ccaf529f5389d6b725
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04431653

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