4,6-Dichloro-5-nitropyrimidine → 4-chloro-6-methoxy-5-nitropyrimidine

HRID 1388892Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1388892
[N+:1]([C:4]1[C:5]([Cl:11])=[N:6][CH:7]=[N:8][C:9]=1Cl)([O-:3])=[O:2].C[CH2:13][O-:14].[Na+]>>[Cl:11][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[C:9]([O:14][CH3:13])[N:8]=[CH:7][N:6]=1

Komponenten

3

Edukt 2

HCID 203124,6-Dichloro-5-nitropyrimidineHCID 2723922Sodium ethoxide

Produkt 1

HCID 2522044-chloro-6-methoxy-5-nitropyrimidineAusbeute 98,3 %

Versuchsvorschrift

100 g 5-nitro 4,6-dichloropyrimidine are heated in 1000 ml sodium ethylate solution (16.8 g sodium) for 10 hours to 50° C. Then the reaction mixture is evaporated under vacuum and the residue is stirred with water and vacuum treated. Subsequently, it is extracted several times with hot petroleum ether (boiling range 40° to 60° C.). After cooling, the crystals are vacuum treated and dried. 46 g 4-chloro-6-methoxy-5-nitropyrimidine are obtained having a melting point of 65° C.

Aufarbeitung

  1. customThen the reaction mixture is evaporated under vacuum
  2. additiontreated
  3. extractionSubsequently, it is extracted several times with hot petroleum ether (boiling range 40° to 60° C.)
  4. temperatureAfter cooling
  5. additiontreated
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a50f6e391acb4900bcd05d226c670c22
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04434167

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