Hydrochloric Acid → 5-(p-Chlorobenzoyl)-2-hydroxycarbonyl-4-methylthio-1-methylpyrrole

HRID 1388927Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1388927
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([C:14]([O:16]C)=[O:15])=[CH:10][C:9]=2[S:18][CH3:19])=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]=2[S:18][CH3:19])=[O:7])=[CH:20][CH:21]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 204690975-(p-Chlorobenzoyl)-2-methoxycarbonyl-4-methylthio-1-methylpyrrole

Produkt 1

HCID 204690825-(p-Chlorobenzoyl)-2-hydroxycarbonyl-4-methylthio-1-methylpyrrole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5-(p-Chlorobenzoyl)-2-methoxycarbonyl-4-methylthio-1-methylpyrrole (39 mg) is dissolved in 1 ml of warm ethanol and 0.5 ml of 2.5 N sodium hydroxide is added. After standing at room temperature for 30 minutes under nitrogen, 0.7 ml of 2.5 N hydrochloric acid is aded. The resulting precipitate is filtered, washed and dried in vacuo to yield the crude 5-(p-chlorobenzoyl)-2-hydroxycarbonyl-4-methylthio-1-methylpyrrole.

Aufarbeitung

  1. filtrationThe resulting precipitate is filtered
  2. washwashed
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-969e2f61c6004931834e3dd1e2667f53
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04434175

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