Hydrochloric Acid → 4-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)

HRID 1389236Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389236
[O:1]([CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:15]>[Pt]=O.CO>[ClH:15].[O:1]([CH2:8][CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 12472531HCID 12472531, Verbindung

Produkt 1

HCID 441449484-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)Ausbeute 53 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 18.5 g (0.1 mole) of 4-phenoxymethylpyridine, 250 ml of methanol, 250 ml of 3 N methanolic hydrogen chloride solution and 2 g of platinum oxide is shaken at ambient temperature under a hydrogen pressure of 1 atmosphere absolute. After the take up of the calculated amount of hydrogen, the catalyst is filtered off, the filtrate is evaporated in a vacuum and the residue is recrystallized from ethanol. There are obtained 12.0 g of 4-phenoxymethylpiperidine hydrochloride (53% of theory); m.p. 218°-219° C. The free base is obtained by treating the hydrochloride with an aqueous solution of sodium hydroxide.

Aufarbeitung

  1. filtrationAfter the take up of the calculated amount of hydrogen, the catalyst is filtered off
  2. customthe filtrate is evaporated in a vacuum
  3. customthe residue is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f4fc3fe9d3f941be8b38728abf96677f
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04243807

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