Hydrogen Bromide → 4-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide
Reaktionsgleichung
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])=[CH:5][CH:4]=1.[BrH:15]>>[BrH:15].[CH3:14][C:10]1[N:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[CH:13]=[CH:12][N:11]=1Komponenten
3
Versuchsvorschrift
A mixture of 4 parts of 1-(4-methoxyphenyl)-2-methyl-1H-imidazole and 37.5 parts of hydrobromic acid solution 48% is stirred and refluxed overnight. After cooling, the reaction mixture is evaporated. The residue is triturated in a mixture of 2-propanone and 2,2'-oxybispropane. The product is filtered off and crystallized from a mixture of ethanol and 2,2'-oxybispropane, yielding 3.8 parts (69%) of 4-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide; mp. 181°-205° C.
Aufarbeitung
- temperaturerefluxed overnight
- temperatureAfter cooling
- customthe reaction mixture is evaporated