2-Mercaptoethanol → 2-[(2-Pyridin-4-ylethyl)thio]ethanol

HRID 1389788

Reaktionsgleichung

Reaktionsgleichung von HRID 1389788
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8]Cl)=[CH:3][CH:2]=1.[SH:10][CH2:11][CH2:12][OH:13]>>[OH:13][CH2:12][CH2:11][S:10][CH2:8][CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

Komponenten

3

Edukt 2

HCID 15672-MercaptoethanolHCID 124817404-(2-Chloroethyl)pyridine

Produkt 1

HCID 20584062-[(2-Pyridin-4-ylethyl)thio]ethanol

Versuchsvorschrift

Using the procedures of Examples 1 to 4, 2-(4-pyridyl)ethyl chloride is reacted with 2-mercaptoethanol to yield 4-[2-(2-hydroxyethylthio)ethyl]pyridine, with 3-mercapto-2-butanol to yield 4-[2-(3-hydroxy-2-butylthio)ethyl]pyridine, with 3-mercapto-1,2-propanediol to yield 4-[2-(2,3-dihydroxy-1-propylthio)ethyl]pyridine, with 2-mercaptophenol to yield 4-[2-(2-hydroxyphenylthio)ethyl]pyridine, with methyl mercaptoacetate (preferably in methanol rather than ethanol solution) to yield methyl 2-[2-(4-pyridyl)ethylthio]acetate and with mercaptoacetone to yield 2-(4-pyridyl)ethylthioacetone.

Quellen und Nachweise

ORD-Eintrag
ord-feddb8d88cda4105bfcc5f75a789c533
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04246263

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