Diethylamine → [(Diethylcarbamoyl)methyl]phosphonic acid

HRID 1390248Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390248
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[C:6]([CH2:9][P:10](=[O:15])([O:13]C)[O:11]C)(O)=[O:7].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH2:1]([N:3]([CH2:4][CH3:5])[C:6]([CH2:9][P:10](=[O:15])([OH:13])[OH:11])=[O:7])[CH3:2]

Komponenten

5

Edukt 3

HCID 8021DiethylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

Produkt 1

HCID 18756985[(Diethylcarbamoyl)methyl]phosphonic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Diethylamine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide was added portionwise. The solution was stirred overnight and the mixture was filtered. The filtrate was concentrated to a solid. It was recrystallized from an appropriate solvent such as methanol.

Aufarbeitung

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture was filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customIt was recrystallized from an appropriate solvent such as methanol

Quellen und Nachweise

ORD-Eintrag
ord-71060c5beb534158a207171f6137d70e
Quelldatensatz
uspto-grants-1979_02
Patentnummer
US04138432

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