Sodium Carbonate → 17beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

HRID 1390730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390730
C(O)(=O)CC.C(O)(=O)CC.[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]2[C@H:18]3[C@H:29]([CH2:30][CH2:31][C@:13]12[CH3:14])[C@:26]1([CH2:27][OH:28])[C:21](=[CH:22][C:23](=[O:33])[CH2:24][C@@H:25]1[CH3:32])[CH2:20][CH2:19]3

Komponenten

4

Edukt 2

HCID 10340Sodium CarbonateHCID 8673472917beta,19-Dihydroxy-1alpha-methyl-4-androsten-3-one dipropionate

Produkt 1

HCID 2279742517beta,19-Dihydroxy-1alphamethyl-4-androsten-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 17β,19-dihydroxy-1α-methyl-4-androsten-3-one dipropionate in methanol is refluxed for two hours with aqueous sodium carbonate. The solvent is removed and the residue dissolved in chloroform. The chloroform solution is washed well with water, dried over magnesium sulfate and evaporated under vacuum. The residue which remains is crystallized from acetonitrile to yield 17β,19-dihydroxy-1α-methyl-4-androsten-3-one.

Aufarbeitung

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in chloroform
  3. washThe chloroform solution is washed well with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated under vacuum
  6. customThe residue which remains is crystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-cd078d86c7494aee833a073e853d6f3d
Quelldatensatz
uspto-grants-1979_02
Patentnummer
US04139617

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