17beta,19-Dihydroxy-4,7alpha-dimethyl-4-androsten-3-one → 17beta,19-Dihydroxy-4alpha,7alpha-dimethyl-5-androsten-3-one

HRID 1390753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390753
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:19]([CH2:20][CH2:21][C@:3]12[CH3:4])[C@:16]1([CH2:17][OH:18])[C:11](=[C:12]([CH3:23])[C:13](=[O:22])[CH2:14][CH2:15]1)[CH2:10][C@H:9]3[CH3:24].[OH:25][C@@:26]1([C:48]#[C:49][CH3:50])[CH2:31][CH2:30][C@H:29]2[C@H:32]3[C@H:43]([CH2:44][CH2:45][C@:27]12[CH3:28])[C@:40]1([CH2:41][OH:42])[C:35](=[CH:36][C:37](=[O:46])[CH2:38][CH2:39]1)[CH2:34][C@H:33]3[CH3:47].O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(CO)C(=CC(=O)CC1)C[C@H]3C>>[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:19]([CH2:20][CH2:21][C@:3]12[CH3:4])[C@:16]1([CH2:17][OH:18])[C:11]([C@H:12]([CH3:23])[C:13](=[O:22])[CH2:14][CH2:15]1)=[CH:10][C@H:9]3[CH3:24].[OH:25][C@@:26]1([C:48]#[C:49][CH3:50])[CH2:31][CH2:30][C@H:29]2[C@H:32]3[C@H:43]([CH2:44][CH2:45][C@:27]12[CH3:28])[C@:40]1([CH2:41][OH:42])[C:35]([CH2:36][C:37](=[O:46])[CH2:38][CH2:39]1)=[CH:34][C@H:33]3[CH3:47]

Komponenten

5

Edukt 3

HCID 5385130017beta,19-Dihydroxy-4,7alpha-dimethyl-4-androsten-3-oneHCID 7058499517beta,19-Dihydroxy-7alpha-methyl-4-androstene-3-oneHCID 13171109717beta,19-Dihydroxy-7alpha-methyl-17alpha-propinyl-4-androsten-3-one

Produkt 2

HCID 7060585417beta,19-Dihydroxy-4alpha,7alpha-dimethyl-5-androsten-3-oneHCID 13171142717beta,19-Dihydroxy-7alpha-methyl-17alpha-propinyl-5-androsten-3-one

Versuchsvorschrift

Substituting 17β,19-dihydroxy-4,7α-dimethyl-4-androsten-3-one, 17β,19-dihydroxy-7α,17α-dimethyl-4-androsten-3-one, 17β,19-dihydroxy-7α-methyl-17α-propinyl-4-androsten-3-one and 7α-methyl-17β,19-di(2'-tetrahydropyranyloxy)-4-androsten-3-one for the 17β,19-dihydroxy-7α-methyl-4-androsten-3-one above results in the formation of 17β,19-dihydroxy-4α,7α-dimethyl-5-androsten-3-one, 17β, 19-dihydroxy-7α,17α-dimethyl-5-androsten-3-one, 17β,19-dihydroxy-7α-methyl-17α-propinyl-5-androsten-3-one and 7α-methyl-17β,19-di(2'-tetrahydropyranyloxy)-5-androsten-3-one, respectively.

Quellen und Nachweise

ORD-Eintrag
ord-bb6096872b3d4e01922e0e966ef867d4
Quelldatensatz
uspto-grants-1979_02
Patentnummer
US04139617

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