HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1392694Erstellt: 27. Oktober 2026
Lithium Hydroxide → 2-(4-Bromophenyl)cyclopropanecarboxylic acid
https://huagongshe.com/reaction/1392694
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
| Lösungsmittel | MeOH tetrahydrofuran | HCID 21899815 | — |
| Produkt | 2-(4-Bromophenyl)cyclopropanecarboxylic acid | HCID 301541 | — |
Reaktionsschritte
To a solution of ester from step 1 in THF-MeOH (4:1, 0.5M) was added LiOH (3 eq, 2M) and the mixture was stirred at 50° C. for 1 h. The organic solvent evaporated, aqueous was acidified with HCl 1N and the acid extracted with EtOAc (3×). The organic was washed with brine, dried and solvent evaporated to afford 2-(4-bromophenyl)cyclopropanecarboxylic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07342024B2 |
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| Quelldatensatz | uspto-grants-2008_03 |
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| ORD ID | ord-8bac66ea71dd4c13863b8312e03e3ee3 |
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| Quellennotiz | uspto-grants-2008_03 |
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