Ethyl bromoacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 1392758

Reaktionsgleichung

[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

4-Chloroaniline (2.0 g) was dissolved in acetonitrile (20 ml), and ethyl bromoacetate (2.1 g) and potassium carbonate (2.2 g) were added to stir the mixture at 60° C. for 2 days. The reaction mixture was filtered through Celite pad, and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1) to obtain the title compound (2.3 g).

Aufarbeitung

filtrationThe reaction mixture was filtered through Celite pad
concentrationthe filtrate was concentrated under reduced pressure
customThe resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1)

Quellen und Nachweise

ORD-Eintrag: ord-ddfb4b074a4041119d5d2fc3840b3ecd
Quelldatensatz: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07342014B2

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